5/05/2007
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David Brent of the University of Pittsburgh School of Medicine. They found that for every 100 treated with antidepressants, about one additional child experienced worsening suicidal feelings above what would have occurred without drug treatment. "At this time nothing indicates a need for change in the 'black box' warning, which urges attention to patients starting treatment," said Dr. But 50 percent of depressed patients taking dummy pills also improved. And in the studies of anxiety disorders, 69 percent improved on antidepressants and 39 percent improved on dummy pills.
"You can't treat kids with these drugs without taking this information into account," said Dr. Scientists are still studying the 1918 pandemic, the deadliest of the 20th century, looking for lessons for future outbreaks including the possibility that H5N1, the avian influenza virus, could mutate into a form spread easily from human to human. "It had been received wisdom that these interventions didn't work" The director for global migration and quarantine at the federal Centers for Disease Control and Prevention in Atlanta, found reason for optimism in the study results.
14, 1918 in high spirits three days after the armistice that ended the war, and with influenza cases declining the city reopened schools and businesses. Louis, carried out early interventions before the first peak, and then reinstituted them when transmission rates began to rise again. When it is your patient who has died, there is a fugitive quality to it: someone has fled, and you were unable to capture or return him alive. He could, however, be found on MySpace.com. There was a photo of him on one side of the screen, handsome and poised, with his astrological sign, educational background and a description of his ideal mate.
In this world, he was a Pisces, not a schizophrenic. I had gone on the site only a day after his death, but his cyberobituary must have traveled faster. Modern medical education can be traced to a series of reforms that began in the late 19th century. One of the most notable occurred at the Johns Hopkins University School of Medicine, where educators initiated a formal system to train students on the clinical wards. The student whose resident seemingly lied to the attending physician about the blood test did not speak up either. Or the student might go directly to the patient or family, telling them that the physicians have a genuine disagreement and that they deserve to know about it. Medical educators are only now beginning to teach this skill. Still, it will be hard to change the unfortunate perception that constructive feedback, even for a patient's benefit, is whistle-blowing. The new analysis, being reported Wednesday in The Journal of the American Medical Association, includes data from seven studies that the previous F.D.A.
They found that for every 100 treated with antidepressants, about one additional child experienced worsening suicidal feelings above what would have occurred without drug treatment. Thomas Laughren, director of the agency's division of psychiatry products. Among young patients with obsessive-compulsive disorders, 52 percent improved on antidepressants, compared with 32 percent who improved on dummy pills.
Two weeks before Philadelphia officials began to react, doctors in St. Infected people were quarantined in their homes. "That we were able to go back and ask the right questions," "When multiple interventions were introduced early, they were very effective in 1918," he said, "and that certainly offers hope that they would be similarly useful in an epidemic today if we didn't have an effective vaccine." "The thing I find encouraging about the Hatchett paper," he said, "is that when you look back to 1918, you find that those who used nonpharmaceutical measures effectively were able to mitigate the impact of the severe pandemics, and this is consistent with some of the 21st-century simulation models." The second study, in the same issue of The Proceedings, suggests that in one sense preventive measures can be too effective. In an influenza epidemic, a certain number of people survive the illness and are immune to reinfection. The researchers analyzed data on 5,310 children and teenagers from 27 studies involving the antidepressants Prozac, Paxil, Zoloft, Celexa, Lexapro, Effexor, Serzone and Remeron. "The medications are safe and effective and should be considered as an important part of treatment," said one co-author of the new analysis, Dr.
David Brent of the University of Pittsburgh School of Medicine. After the warning, suicides among American youth increased, and some mental health experts said reluctance to try antidepressants might be to blame. Among those studies were two large pediatric depression trials whose results were unavailable three years ago.
"At this time nothing indicates a need for change in the 'black box' warning, which urges attention to patients starting treatment," said Dr. They worked less well, though still effectively, in treating depression. But he said the suicidal behavior risk, although lower than found by the F.D.A., demanded that doctors and families watch for warning signs. Early action appeared to have saved thousands of lives. Hatchett said, "is a function of a lot of modeling work that we did previously." In an influenza epidemic, a certain number of people survive the illness and are immune to reinfection. If restrictions were introduced too late or lifted too early, success rates declined substantially. Ferguson said, "we would start a crash program to make a vaccine. By these criteria, my patient could not be found on the map (though psychosis is also a high risk factor).
He could, however, be found on MySpace.com. The researchers analyzed data on 5,310 children and teenagers from 27 studies involving the antidepressants Prozac, Paxil, Zoloft, Celexa, Lexapro, Effexor, Serzone and Remeron. "The medications are safe and effective and should be considered as an important part of treatment," said one co-author of the new analysis, Dr.
"At this time nothing indicates a need for change in the 'black box' warning, which urges attention to patients starting treatment," said Dr. Thomas Laughren, director of the agency's division of psychiatry products.
The researchers analyzed data on 5,310 children and teenagers from 27 studies involving the antidepressants Prozac, Paxil, Zoloft, Celexa, Lexapro, Effexor, Serzone and Remeron. Thomas Laughren, director of the agency's division of psychiatry products. The new analysis found that antidepressants worked best when used to treat anxiety. The risk found by the researchers is lower than one that the Food and Drug Administration identified in 2004, the year the agency warned the public about the drugs' risks in children. "The medications are safe and effective and should be considered as an important part of treatment," said one co-author of the new analysis, Dr. They worked less well, though still effectively, in treating depression. March, who was not involved in the study but who does similar research.
"You can't say, 'Take these and call me in six weeks. " Louis persuaded the city to require that influenza cases be registered with the health department. Infected people were quarantined in their homes.
Using mathematical models, they reported that such large differences in death rates could be explained by the ways the cities carried out prevention measures, especially in their timing. "When multiple interventions were introduced early, they were very effective in 1918," he said, "and that certainly offers hope that they would be similarly useful in an epidemic today if we didn't have an effective vaccine."
