5/11/2007

 

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"The thing I find encouraging about the Hatchett paper," he said, "is that when you look back to 1918, you find that those who used nonpharmaceutical measures effectively were able to mitigate the impact of the severe pandemics, and this is consistent with some of the 21st-century simulation models." The study examined the course of the epidemic in 23 cities: San Francisco, St. If restrictions were introduced too late or lifted too early, success rates declined substantially. No one is immune from contemplating suicide. Finding him there after death seemed imperative.
They were not written to a haunted self, or someone who had failed trials of antipsychotic drugs, or someone who had been hospitalized again and again under duress. By now, of course, the messages had no recipient, and the friends my patient had made were writing to one another. Doctors in training sometimes confront situations in which they worry that their supervising physicians are making mistakes or bending the truth. Although some senior physicians welcomed feedback from their juniors, others disdained it, either overtly or through intimidation.
Wolfberg wrote in the same journal last month, for years medical students performed pelvic examinations on anesthetized women who had not given consent because senior obstetricians said it was the best way to learn internal anatomy. March, who was not involved in the study but who does similar research. Two weeks before Philadelphia officials began to react, doctors in St. Cities that instituted quarantine, school closings, bans on public gatherings and other such procedures early in the epidemic had peak death rates 30 percent to 50 percent lower than those that did not. "It had been received wisdom that these interventions didn't work"
The director for global migration and quarantine at the federal Centers for Disease Control and Prevention in Atlanta, found reason for optimism in the study results. The second study, in the same issue of The Proceedings, suggests that in one sense preventive measures can be too effective.
As these numbers increase, the epidemic fades. If restrictions were introduced too late or lifted too early, success rates declined substantially. Louis, carried out early interventions before the first peak, and then reinstituted them when transmission rates began to rise again. Demographic studies show that the population most at risk is single, urban, substance-abusing older white men with physical illness, few supports and low incomes. Finding him there after death seemed imperative. They were not written to a haunted self, or someone who had failed trials of antipsychotic drugs, or someone who had been hospitalized again and again under duress. Nor, apparently, was that unseen self writing back.
Doctors in training sometimes confront situations in which they worry that their supervising physicians are making mistakes or bending the truth. On the top were the senior physicians who made rounds on the wards once or twice daily. Last were the medical students, who spent the most time with patients but were most assuredly at the bottom of the heap.
Although this practice made many students uncomfortable, most were afraid to speak up. The student admitted that he was far from positive that something was seriously wrong.Or the student might go directly to the patient or family, telling them that the physicians have a genuine disagreement and that they deserve to know about it. Students and residents are now expected to provide routine feedback — positive and negative — about their supervising physicians at the close of their rotation. Still, it will be hard to change the unfortunate perception that constructive feedback, even for a patient's benefit, is whistle-blowing. Back she went to Raheen, flattered and excited, only to be outfoxed by the wily Irish charmer, then ninety-five and giving nothing away. Because of the stringencies of their order (the Faithful Companions of Jesus), theirs was hardly a vibrant intellectual climate, and young Brenda's reading – including Graham Greene – soon intimidated the author-ities.
Before the late 1940s, each state had just one university. Benefits flowed too in socio-economic terms; an Australian Council of Education Research study con-cluded the proportion of children of unskilled manual workers going to university nearly doubled between 1980 and 1994. But he said the suicidal behavior risk, although lower than found by the F.D.A., demanded that doctors and families watch for warning signs. Early action appeared to have saved thousands of lives.
Richard Hatchett, the lead author of one of the studies, "because they looked at the variability between cities and concluded that there was some other factor than the interventions that caused the differing outcomes. In an influenza epidemic, a certain number of people survive the illness and are immune to reinfection. Two weeks later, the second wave of the epidemic struck, this time with children making up 30 percent to 40 percent of the infections. Ferguson said, is to tune an imperfect intervention perfectly so that a single peak of minimal size is the result. When it is your patient who has died, there is a fugitive quality to it: someone has fled, and you were unable to capture or return him alive.
I knew about his voices, and sometimes knew what his voices told him, but had come to believe that voices and patient coexisted in a delicate yet stable ecosystem. Adolescents responded better than children to treatment for depression and anxiety, the researchers found.
"You can't treat kids with these drugs without taking this information into account," said Dr. March, who was not involved in the study but who does similar research. "You can't say, 'Take these and call me in six weeks. " And in the studies of anxiety disorders, 69 percent improved on antidepressants and 39 percent improved on dummy pills. "You can't treat kids with these drugs without taking this information into account," said Dr. March, who was not involved in the study but who does similar research. Louis persuaded the city to require that influenza cases be registered with the health department.
Louis were 347 per 100,000 people, less than half the rate in Philadelphia. Cities that instituted quarantine, school closings, bans on public gatherings and other such procedures early in the epidemic had peak death rates 30 percent to 50 percent lower than those that did not. "That we were able to go back and ask the right questions,"
The second study, in the same issue of The Proceedings, suggests that in one sense preventive measures can be too effective. As these numbers increase, the epidemic fades.Louis, carried out early interventions before the first peak, and then reinstituted them when transmission rates began to rise again. The criteria are so specific it's like putting pins in a war map. On the opposite side of the screen, there were scrolls of e-mail messages that other MySpace members had sent him: friendly, uncapitalized, hallucination-free greetings. Some voiced hopes of meeting one day, some had comments about other correspondents on the site, some sent good wishes on relevant holidays. They were not written to a haunted self, or someone who had failed trials of antipsychotic drugs, or someone who had been hospitalized again and again under duress.
They were an introduction to a man I had not properly known. I had gone on the site only a day after his death, but his cyberobituary must have traveled faster. By now, of course, the messages had no recipient, and the friends my patient had made were writing to one another. They also found that only Prozac worked better than dummy pills in depressed children younger than 12.
Among young patients with obsessive-compulsive disorders, 52 percent improved on antidepressants, compared with 32 percent who improved on dummy pills. And two days after the first civilian cases, police officers helped the department enforce a shutdown of schools, churches and other gathering places. Louis were 347 per 100,000 people, less than half the rate in Philadelphia. Cities that instituted quarantine, school closings, bans on public gatherings and other such procedures early in the epidemic had peak death rates 30 percent to 50 percent lower than those that did not. "When multiple interventions were introduced early, they were very effective in 1918," he said, "and that certainly offers hope that they would be similarly useful in an epidemic today if we didn't have an effective vaccine."
In an influenza epidemic, a certain number of people survive the illness and are immune to reinfection. Two weeks later, the second wave of the epidemic struck, this time with children making up 30 percent to 40 percent of the infections.
Louis, Milwaukee and Kansas City, Mo., had the most effective prevention programs, and time was of the essence. If restrictions were introduced too late or lifted too early, success rates declined substantially. Although no cities succeeded in doing this, those that got closest, like St. Louis, carried out early interventions before the first peak, and then reinstituted them when transmission rates began to rise again. But 50 percent of depressed patients taking dummy pills also improved. "You can't say, 'Take these and call me in six weeks. " Scientists are still studying the 1918 pandemic, the deadliest of the 20th century, looking for lessons for future outbreaks — including the possibility that H5N1, the avian influenza virus, could mutate into a form spread easily from human to human.
Using mathematical models, they reported that such large differences in death rates could be explained by the ways the cities carried out prevention measures, especially in their timing. "It had been received wisdom that these interventions didn't work" A two-week difference in response times, according to the researchers, is long enough for the number of people infected in an influenza epidemic to double three to five times.
In an influenza epidemic, a certain number of people survive the illness and are immune to reinfection. As these numbers increase, the epidemic fades.




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